“…Mr. Borges-Silva, thank you so much for your personal response.
“One of the biggest mistakes the EPA has made is relying on
single-substance animal tests, often performed by the pesticide companies, to
assess toxicity. Rats and mice are not perfect human models and do not
have the longer latency period of humans. These single-substance tests
also do not factor in synergistic effects with other chemicals to which we are
all exposed (CDC); this is the most likely reason that the best epidemiological
studies show very different results compared to animal studies. And all
this explains why the President’s Cancer Panel (PCP) Report of 2010 and the
American Academy of Pediatrics (AAP) in 2013 assign much of the blame for
rising cancer rates in children to virtually unregulated pesticide exposures.
“Organophosphates, the class to which chlorpyrifos belongs, have
long been implicated in epidemiological studies of childhood leukemia (Zahm and
Ward 1998; Meinert et al. 2000; Infante-Rivard and Weichenthal 2007); now in
addition to teasing out this particular class of chemicals, studies are starting
to use direct measures, like metabolite levels in urine and biomarkers of
toxicity, to assign blame to particular substances (Soldin et al. 2009; Amaroli
et al. 2013).
“One recent study points out that the finding that insecticides
like organophosphates, organochlorines, and pyrethroids are particularly linked
to brain cancer is ‘interesting’ because these class of insecticides ‘readily
cross the blood-brain barrier and target the nervous system, whereas pesticides
aimed at plants and fungi inherently rely on different mechanisms of action’
(Nielson et al. 2010).
“New research argues that chlorpyrifos may be responsible for
increased levels of cancer, not because it damages DNA directly, but because it
depresses immune and neurochemical activity (Perry and Soreq 2004; Amaroli et
al. 2013) or causes oxidative stress, endocrine disruption, and cholinesterase
inhibition (Rull et al. 2009).
“Our eight-year-old daughter Katherine died in 2002 of leukemia we
have every reason to believe was caused by her unwitting exposure to
chlorpyrifos, so we have followed the evidence carefully for years. We
thought she was protected when chlorpyrifos was banned for residential use in
2001, but there was a loophole for mosquito spraying, which we did not realize
had occurred from her infancy onwards. We know your hands are tied by the
weakness of TSCA. The Safe Chemicals Act, sponsored by Frank Lautenberg,
would be a step in the right direction; but in the meantime, you at the EPA are
all that protects our children, and you have largely failed to do so, not just
by our accounting, but according to the PCP and AAP. Having an
Environmental Protection Agency gives people the illusion that they are
protected from environmental exposures, when nothing could be further from the
truth. Registration implies to most people that the chemicals in question
have been thoroughly researched and have negligible human health risks.
That is simply not the case.
“Could you please pass this on as a request for re-registration of
chlorpyrifos and other organophosphate chemicals in light of more recent and
epidemiological evidence?”
Thank you–
Jean-Marie Kauth, PhD
Craig W. Colling, PhD
References
American Academy of Pediatrics (AAP). 2012. Policy
statement: Pesticide exposure in children. Pediatrics 130(6):e1757-e1763.
Amaroli A, Aluigi MG, Falugi C, Chessa MG. 2013.
Effects of the neurotoxic thionophosphate pesticide chlorpyrifos on
differentiating alternative models. Chemosphere 90:2115-2122.
Centers for Disease Control and Prevention (CDC). Fourth National
Report on Human Exposure to Environmental Chemicals. Atlanta (GA). 2005.
Infante-Rivard C, Weichenthal S. 2007. Pesticides and
childhood cancer: An update of Zahm and Ward’s 1998 review. J Toxicol
Environ Health, Part B 10:81-99.
Meinert R, Schüz J, Kaletsch U, Kaatsch P, Michaelis J.
2000. Leukemia and Non-Hodgkin’s Lymphoma in childhood and exposure to
pesticides: Results of a register-based case-control study in Germany.
Epidemiology 151(7):639-646.
Nielson SS, McKean-Cowdin R, Farin FM, Holly EA, Preston-Martin S,
Mueller BA. 2010. Childhood brain tumors, residential insecticide
exposure, and pesticide metabolism genes. Environ Health Perspect
118(1):144-149.
Perry C, Soreq H. 2004. Organophosphate risk of
leukemogenesis. Leukemia Research 28: 905-906.
President’s Cancer Panel (PCP). 2010. Reducing
Environmental Cancer Risk: What We Can Do Now. U.S. Department of Health
and Human Services.
Rull RP, Gunier R, Von Behren J, Hertz A, Crouse V, Buffler PA,
Reynolds P. 2009. Residential proximity to agricultural pesticide
applications and childhood acute lymphoblastic leukemia. Environmental
Research 109:891-899.
Soldin OP, Nsouly-Maktabi H, Genkinger JM, Loffredo CA,
Ortega-Garcia JA, Colantino D, Barr DB, Luban NL, Shad AT, Nelson D.
2009. Pediatric acute lymphoblastic leukemia and exposure to
pesticides. Ther Drug Monit 31(4):495-501.
Zahm SH, Ward S. 1998. Pesticides and childhood
cancer. Environ Health Perspect Suppl 106:893.
This is a serious and important correspondence between
Jean-Marie Kauth and the Environmental Protection Agency. Please read the
complete exchange at http://poisoningourchildren.wordpress.com/2014/02/10/corresponding-with-the-epa/
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.