A Prospective Cohort
Study:
Matthew
P. Pase, Jayandra J. Himali, Alexa S. Beiser, Hugo J. Aparicio, Claudia L.
Satizabal, Ramachandran S. Vasan, Sudha Seshadri, Paul F. Jacques
Originally published
April 20, 2017
Abstract:
Background
and Purpose— Sugar
and artificially-sweetened beverage intake have been linked to cardio-metabolic
risk factors, which increase the risk of cerebrovascular disease and dementia.
We examined whether sugar- or artificially sweetened beverage consumption was
associated with the prospective risks of incident stroke or dementia in the
community-based Framingham Heart Study Offspring cohort.
Methods—
We studied
2888 participants aged >45 years for incident stroke (mean age 62 [SD, 9]
years; 45% men) and 1484 participants aged >60 years for incident dementia
(mean age 69 [SD, 6] years; 46% men). Beverage intake was quantified using a
food-frequency questionnaire at cohort examinations 5 (1991–1995), 6
(1995–1998), and 7 (1998–2001). We quantified recent consumption at examination
7 and cumulative consumption by averaging across examinations. Surveillance for
incident events commenced at examination 7 and continued for 10 years. We
observed 97 cases of incident stroke (82 ischemic) and 81 cases of incident
dementia (63 consistent with Alzheimer’s disease).
Results—
After
adjustments for age, sex, education (for analysis of dementia), caloric intake,
diet quality, physical activity, and smoking, higher recent and higher
cumulative intake of artificially sweetened soft drinks were associated with an
increased risk of ischemic stroke, all-cause dementia, and Alzheimer’s disease
dementia. When comparing daily cumulative intake to 0 per week (reference), the
hazard ratios were 2.96 (95% confidence interval, 1.26–6.97) for ischemic
stroke and 2.89 (95% confidence interval, 1.18–7.07) for Alzheimer’s disease.
Sugar-sweetened beverages were not associated with stroke or dementia.
Conclusions—
Artificially-sweetened
soft drink consumption was associated with a higher risk of stroke and
dementia.
To
Download the study, click here.
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.