“The Rush Alzheimer’s Disease Center at Rush University
Medical Center is the only site in Illinois, and one of only 15 sites across
the United States leading the Exercise in Adults With Mild Memory Problems
(EXERT) study, which is trying to determine if exercise can slow the progress
of memory loss and cognitive impairment in older adults.
“Neuroscientists are collaborating with the YMCA to provide
individualized, one-on-one exercise programs and personal training to study
participants. Rush will be working with the McGaw YMCA in Evanston, Illinois,
to provide 45-minute personal training sessions for one year.
“‘We want to see if a personalized program implemented in
the community and prescribed by health care providers can be an effective
therapy for people with memory issues,’ said Dr. Neelum Aggarwal, associate
professor of neurology and principal investigator of the EXERT study at Rush. ‘There
have been some studies suggesting that exercise may be able to delay or prevent
dementia,’ Aggarwal continued. ‘The EXERT study is a longer trial looking at a
larger number of participants who have short-term memory loss that may be
impacting some aspect of their day-to-day functioning.’
“‘Some older adults shy away from social situations or being
active because of their memory issues during a time when they need it the most,’
said Aggarwal. ‘The personalized, one-on-one attention from a program
like this may be more beneficial for them.’
“The Rush portion of the EXERT study will be enrolling 300
people ages 65 to 89 with mild memory loss – also known as mild cognitive
impairment, a condition that often precedes Alzheimer’s disease dementia. The
study is looking to enroll people who are not as active, because people who are
physically fit may already be at peak brain function. To qualify for the trial,
participants may have engaged in casual, low-intensity physical activity, but
not rigorous exercise.
“Based on the trial results, neurological researchers are
hoping to develop an evidence-based program that will tell people the type and
frequency of exercise they need to support memory and thinking skills. All
trial participants will receive a free membership at the participating YMCA
where they will work closely with a personal trainer for one year. Participants
then will exercise on their own for an additional six months.
“Participants will be randomly assigned to one of two
groups. The ‘high-intensity’ group will walk on a treadmill and take exercise
classes that raise their heart rate to 75 percent of capacity. The ‘low-intensity’
group will do stretching, balance and range-of-motion exercises. All
participants will work out in four 45-minute sessions per week.
“In addition, they will undergo the following tests and
procedures at the beginning of the trial and then every six months:
- Memory and other tests to measure changes in thinking and memory
- Magnetic resonance imaging (a type of brain scan) to measure changes in brain blood flow and brain size and structure
- Collection of blood and cerebrospinal fluid to measure Alzheimer’s-related changes.
“Walking fitness tests and sleep studies are also part of
the trial. The study is part of the NIA-supported Alzheimer’s Disease
Cooperative Study, a consortium of universities and research centers in the
United States and Canada.”
For more information about the EXERT study, contact the Rush
Alzheimer’s Disease Center at (312) 942-0500.
Media contact:
Deb Song, (312) 942-0588, deb_song@rush.edu
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